MRIs and CTs can be used to scan the brain and orbits. Chromosomal abnormalities are only a minority of cases of anophthalmia. Amniocentesis can only diagnose anophthalmia when there is a chromosomal abnormality. It is possible to diagnose prenatally with amniocentesis, but it may not show a correct negative result. The earliest time to detect anophthalmia this way is approximately 20 weeks. Due to the resolution of the ultrasound, it is difficult to diagnose it until the second trimester. Ultrasounds can be used to diagnose anophthalmia during gestation. One reason for this occurring could be a lack of blood supply to the eye.
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